Dr David Leaver


Assistant Professor of Chemistry
Biology, Geology, & Physical Sciences
djl14jh@sulross.edu
(432) 837-8115
Fax: (432) 837-8682
Office: WSB 318
Address: Box C-64, Alpine, TX 79832


Lectures:  General Chemistry I & II, Biochemistry I & II, Organic Chemistry I & II.  Research interests are focused on organic chemistry/medicinal chemistry/chemical biology.  Current research interests include the development of monovalent and multivalent carbohydrate derivatives that can be used to inactivate toxins such as cholera toxin, heat-labile enterotoxin, etc., the development of novel sterol biosynthesis inhibitors that could be used to treat neglected parasitic diseases such as Chagas, Human African Trypanosomiasis, etc., and the development of small molecular chemical probes.

BSc (Hons) La Trobe University (2008), Melbourne, Australia; PhD La Trobe University (2012), Melbourne, Australia; Post-doctoral Research Fellow at Monash University (2012-2013), Australia; Post-doctoral Research Fellow at Texas Tech University (2013-2014), United States of America & Nanjing University (2013-2014), Jiangsu, P.R. of China.

 

SELECTED PUBLICATIONS:
   

     1.  David J. Leaver, Presheet Patkar, Ujjal K. Singha, Matthew B. Miller, Brad A. Haubrich,
          Minu Chaudhuri and W. David Nes, Fluorinated Sterols Are Suicide Inhibitors of
          Ergosterol Biosynthesis and Growth in Trypanosoma brucel", Chemistry and Biology, 22,
          1374-1383, 2015

     2.  Fabio R. Santori, Pengxiang Huang, Serge A. van de Pavert, Eugene F. Douglas Jr, David
          J. Leaver, Brad A. Haubrich, Rok Keber, Gregor Lorbek, Tanja Konijn, Brittany N.  
          Rosales, Damjana Rozman, Simon Horvat, Alain Rahier, Reina E. Mebius, Fraydoon
          Rastinejad, W. David Nes and Dan R. Littman, "Identification of Natural ROR Ligands
          that Regulate the Development of Lymphoid Cells"  Cell Metabolism (Impact factor
          16.747), 21, 286-297, 2015

      3.  Brad A. Haubrich, Ujjal K. Singha, Matthew B. Miller, Craigen R. Nes, Hossana
          Anyatonwu, Laurence Lecordier, Presheet Patkar, David J. Leaver,
          Fernando Villalta, Benoit Vanhollebeke, Minu Chaudhuri and W. David Nes, "Discovery
          of an ergosterol-signaling factor that regulates Ttypanosoma brucei growth", Journal of
          Lipid Research
, 56, 331-341, 2015

     4.  David J. Leaver, Andrew B. Hughes, Raymond M. Dawson, Almar Postma, Nino Malic
          and Anastasios Polyzos, "Synthesis of RAFT Polymers as Bivalent Inhibitors of Cholera
          Toxin"  RSC Advances, 4, 14868-14871, 2014

     5.  David J. Leaver, Raymond M. Dawson, Johnathan M., White, Anastasios Polyzos and
          Andrew B. Hughes, "Synthesis of 1,2,3-Triazole Linked Galactopyranosides and
          Evaluation of Cholera Toxin Inhibition" Organic & Biomolecular Chemistry, 9, 8465-
          8474, 2011